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Upscaling of a fermentation process for recombinant protein production

  • 2018


Scaling up of a fermentation process  for the production of a recombinant protein with a methylotrophic yeast:

  • Streams adaptation
  • Fed-batch fermentation
  • Culture centrifugation
  • Biomass storage and delivery


  • Adaptation of the process to the pilot plant and inoculum train preparation.
  • Fermentation in 100 L bioreactor, including analytics to determine the evolution of the process.
  • Data recording of relevant process parameters.
  • Separation of the supernatant for pellet recovery
  • Delivery to customer
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